- JOB
- France
3 May 2025
Job Information
- Organisation/Company
- CNRS
- Department
- Institut de génétique moléculaire de Montpellier
- Research Field
- Biological sciences » Biology
- Researcher Profile
- First Stage Researcher (R1)
- Country
- France
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Full-time
- Hours Per Week
- 35
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- Not funded by a EU programme
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
The PhD. student will be supervised by Dr Cyril Esnault (Institut de Génétique Moléculaire de Montpellier - IGMM, Montpellier) and Dr Manoel Manghi (Laboratoire de Physique Théorique de Toulouse - LPT, Toulouse) on an interdisciplinary project (Biology/Physics) funded by the CNRS via an 80 prime grant. She or he will be based in Montpellier at the IGMM and will work in close collaboration between the 2 teams. The Institut de Génétique Moléculaire de Montpellier is a joint CNRS and Université de Montpellier research unit, with 180 staff divided into 18 research groups, 9 shared services (5 of which are shared with other units on the CNRS campus) and 9 technological and scientific platforms. The IGMM is a multidisciplinary institute whose work has an international impact, both fundamental and applied, in molecular and cellular biology (www.igmm.cnrs.fr).
We are looking for a motivated and dynamic student with knowledges in both physics and biology to carry out our scientific project, which aims to study how mechanical stimuli influence the organization of the nucleus and gene expression programs.
Informations: https://www.igmm.cnrs.fr/en/team/transcription-epigenomique-dans-les-ce…
3D genome organization and regulation of gene expression in response to mechanical cues.
Where to apply
Requirements
- Research Field
- Biological sciences
- Education Level
- Master Degree or equivalent
- Languages
- FRENCH
- Level
- Basic
- Research Field
- Biological sciences » Biology
- Years of Research Experience
- None
Additional Information
Additional comments
All the cells of a mammalian organism share the same genome which derives from the two parental gametes. Despite this genetic identity, most cells in an individual differ. This depends, for example, on the tissue or their functions. This phenomenon is largely controlled by the regulation of gene expression programs, on which environmental signals such as growth factors or hormones play an essential role. In addition to these biochemical signals, cells respond to physical constraints: stretch, compression and rigidity of the extracellular matrix (ECM). The elasticity of the ECM is of critical physio-pathological importance: it promotes tumor invasion and regulates stem cell differentiation. The aim of our project is to understand how these constraints affect the 3D genome organization to regulate its expression, using (i) genomics and genetic tools and (ii) physics modelling and Brownian dynamics simulations. This goal could ultimately enable us to control these mechanisms.
- Website for additional job details
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Institut de génétique moléculaire de Montpellier
- Country
- France
- City
- MONTPELLIER
- Geofield
Contact
- City
- MONTPELLIER
- Website